P63、Calponin和D2-40在涎腺肿瘤肌上皮细胞中的表达及意义

doi:10.3969/j.issn.1004-616x.2011.01.014

›› 2011, Vol. 23 ›› Issue (1): 54-057.doi: 10.3969/j.issn.1004-616x.2011.01.014

P63、Calponin和D2-40在涎腺肿瘤肌上皮细胞中的表达及意义

唐文军,周静萍

皖南医学院口腔内科教研室，安徽芜湖 241000

收稿日期:2010-08-01 修回日期:2010-10-14 出版日期:2011-01-30 发布日期:2011-01-30

Expressions and clinical significance of P63,Calponin and D2-40 in myoepithelial cells of salivary gland tumors

TANG Wen-jun, ZHOU jing-ping

Department of Oral Medicine, Wannan Medical College, Wuhu 241000, Anhui, China

Received:2010-08-01 Revised:2010-10-14 Online:2011-01-30 Published:2011-01-30

摘要/Abstract

摘要： 分析P63、Calponin、D2-40在各型涎腺肿瘤肌上皮细胞中的表达情况，探讨D2-40标记涎腺肿瘤肌上皮细胞的价值。方法：收集附属弋矶山医院2004年1月至2010年1月的6年间，手术切除的各型涎腺肿瘤标本切片作为研究材料。采用免疫组化SP法检测各型涎腺肿瘤组织中P63、Calponin、D2-40的表达。结果： P63、Calponin、D2-40均表达于肌上皮细胞，在各型涎腺肿瘤中总的表达率分别为82.14%、76.79%、66.07%。D2-40在多形性腺瘤、腺样囊性癌、上皮-肌上皮癌均有表达，表达率分别为94.12%、61.90%、66.67%，在恶性多形性腺瘤中未见表达。D2-40在多形性腺瘤、涎腺恶性肿瘤的癌旁组织、癌组织中均出现阳性表达，并以此为序其阳性表达率呈递减趋势，且3者间表达率的差异具有统计学意义(P＜0.05)。结论：D2-40是一种较好的涎腺肿瘤肌上皮细胞的标记物；D2-40的低水平表达可能是涎腺肿瘤恶化的活跃指标之一。

关键词: p63, Calponin, D2-40, 腺肿瘤, 肌上皮细胞

Abstract: To analyze the expressions of P63, Calponin and D2-40 in myoepithelial cells of salivary gland tumors and to investigate the value of D2-40 in identification of myoepithelial cells in salivary gland tumor. METHODS: Various types of salivary gland tumor specimens were collected during surgeries in affiliated Yijishan Hospital from January 2004 to January 2010. We used immunohistochemical technique (S-P) to examine the expressions of P63, Calponin and D2-40 in each salivary gland tumor organization. RESULTS: P63, Calponin, D2-40 were expressed in myoepithelial cells, and the expressions of P63, Calponin, D2-40 were 82.14%, 76.79% and 66.07%, respectively. D2-40 was expressed in polymorphic adenomas, adenoid cystic carcinoma, epithelial-myoepithelial carcinoma and the expressions were 94.12%, 61.90% and 66.67%, respectively. D2-40 was not expressed in malignant polymorphic adenomas. The expression of D2-40 in polymorphic adenomas, tissues adjacent to the salivary gland malignancy and the cancerous tissues showed decreasing expressions that were significant (P＜0.05). CONCLUSION: D2-40 could be one kind of ideal salivary gland tumor myoepithelial cell marker. Low expression of D2-40 is probably an indicator of malignant progresion of salivary gland tumor.

Key words: P63, Calponin, D2-40, salivary gland tumors, myoepithelial cell

唐文军,周静萍. P63、Calponin和D2-40在涎腺肿瘤肌上皮细胞中的表达及意义[J]. , 2011, 23(1): 54-057.

TANG Wen-jun, ZHOU jing-ping. Expressions and clinical significance of P63,Calponin and D2-40 in myoepithelial cells of salivary gland tumors[J]. , 2011, 23(1): 54-057.

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P63、Calponin和D2-40在涎腺肿瘤肌上皮细胞中的表达及意义

Expressions and clinical significance of P63,Calponin and D2-40 in myoepithelial cells of salivary gland tumors

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